Introgression of the Kinetoplast DNA: An Unusual Evolutionary Journey in Trypanosoma cruzi
نویسندگان
چکیده
منابع مشابه
The presence of basic proteins associated to the kinetoplast-DNA of Trypanosoma cruzi epimastigotes. Short communication.
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BACKGROUND The Trypanosoma cruzi satellite DNA (satDNA) OligoC-TesT is a standardised PCR format for diagnosis of Chagas disease. The sensitivity of the test is lower for discrete typing unit (DTU) TcI than for TcII-VI and the test has not been evaluated in chronic Chagas disease patients. METHODOLOGY/PRINCIPAL FINDINGS We developed a new prototype of the OligoC-TesT based on kinetoplast DNA ...
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Trypanosomes have an unusual mitochondrial genome, called kinetoplast DNA, that is a giant network containing thousands of interlocked minicircles. During kinetoplast DNA synthesis, minicircles are released from the network for replication as theta-structures, and then the free minicircle progeny reattach to the network. We report that a mitochondrial protein, which we term p38, functions in ki...
متن کاملThe trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.
Due to limited efficacy and considerable toxicity, the therapy for Chagas' disease is far from being ideal, and thus new compounds are desirable. Diamidines and related compounds such as arylimidamides have promising trypanocidal activity against Trypanosoma cruzi. To better understand the mechanism of action of these heterocyclic cations, we investigated the kinetoplast DNA (kDNA) binding prop...
متن کاملGenomic organization of Trypanosoma brucei kinetoplast DNA minicircles.
The sequences of seven new Trypanosoma brucei kinetoplast DNA minicircles were obtained. A detailed comparative analysis of these sequences and those of the 18 complete kDNA minicircle sequences from T. brucei available in the database was performed. These 25 different minicircles contain 86 putative gRNA genes. The number of gRNA genes per minicircle varies from 2 to 5. In most cases, the gene...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2018
ISSN: 1389-2029
DOI: 10.2174/1389202918666170815124832